1. S. Cai, Y. Xie, T. Bagby, M.S. Cohen, M.L. Forrest. “Intralymphatic chemotherapy using a hyaluronan-cisplatin conjugate. J. Surg. Res. 147(2): 247-252 (2008). PMID: 18498877. Featured on issue cover.
  2. M.S. Cohen, S. Cai, M.L. Forrest. “A Novel Intralymphatic Nanocarrier-Delivery System for Cisplatin Therapy in Breast Cancer with Improved Tumor Efficacy and Lower Systemic Toxicity In Vivo.Am. J. Surg., 198(6):781-6 (2009). PMID 19969129.
  3. S. Cai, Y. Xie, N.M. Davies, M.S. Cohen, M.L. Forrest. “Pharmacokinetics and disposition of a localized lymphatic polymeric hyaluronan conjugate of cisplatin in rats.J. Pharm. Sci., 99(6):2664-71 (2010). PMID: 19960530
  4. Y. Xie, K.L Aillon, S. Cai, J.M. Christian, N.M. Davies, C.J. Berkland, M.L. Forrest. “Pulmonary delivery of cisplatin-hyaluronan conjugates via endotracheal instillation for the treatment of lung cancer.Intl. J. Pharm. 392(1-2):156-63 (2010). PMID: 20363303
  5. S. Cai, S. Thati, T.R. Bagby, H-M. Diab, N.M. Davies, M.S. Cohen, M.L. Forrest. “Localized doxorubicin chemotherapy with a biopolymeric nanocarrier improves survival and reduces toxicity in xenografts of human breast cancer.J. Control. Rel. 146(2):212-218 (2010). PMID: 20403395
  6. S. Cai, N.M. Davies, M.S. Cohen, M.L. Forrest. “Carrier-based intralymphatic cisplatin chemotherapy for the treatment of metastatic squamous cell carcinoma of the head & neck.Ther. Deliv. 1(2):237-245 (2010). PMID: 21339844
  7. S.M. Cohen, R. Mukerji, S. Cai, I. Damjanov, M.L Forrest, M.S. Cohen*. “Subcutaneous delivery of nanoconjugated doxorubicin and cisplatin for locally advanced breast cancer demonstrate improved efficacy and decreased toxicity at lower doses than standard systemic combination therapy in vivo.Am. J. Surg. 202(6):646-653 (2011) * co-corresponding authors PMID: 21982998.
  8. S. Cai, T. Bagby, M.L.Forrest. “Development of regional chemotherapies: feasibility, safety and efficacy in clinical use and preclinical studies.Ther. Deliv. 2(11):1467-1484 (2011). PMID: 22229080
  9. S. Duan, S. Cai, Q. Yang, M. L. Forrest. “Multi-arm polymeric nanocarrier as a nitric oxide delivery platform for chemotherapy of head and neck squamous cell carcinomaBiomaterials 33(11):3243-3253 (2012) NIHMSID #350039
  10. R. Venable, D. Worley, D. Gustafson, R. Hansen, E.J. Ehrhart, S. Cai, M. Cohen, M.L. Forrest. “Hyaluronan cisplatin conjugate in five dogs with soft tissue sarcomas.Am. J. Vet. Res. 73(12):1969-76 (2012). PMID: 23176425
  11. T.R. Bagby, S. Duan, S. Thati, S. Cai, C. Berkland, D. Aires, M.L. Forrest. “Lymphatic trafficking kinetics and near-infrared imaging using star polymer architectures with controlled anionic character”. Eur. J. Pharm. Sci. 47(1):287-94. PMID 22546180
  12. Xie, Y, M.S. Cohen, M.L. Forrest.Drug Delivery to the Lymphatic System: Importance in Future Cancer Diagnosis and Therapies.Expert Opin. Drug Deliv., 6:785-92 (2009). PMID: 19563270.
  13. T.R. Bagby, S. Cai, S. Duan, S. Thati, D.J. Aires, L. Forrest.Impact of Molecular weight on Lymphatic drainage of a biopolymer-based imaging agent.” Pharmaceutics 4:276-95 (2012).
  14. S.K. Nune, P. Gunda, B.K. Majeti, P.K. Thallapally, M.L. Forrest.Advances in lymphatic imaging and drug delivery.Adv. Drug. Deliv. Rev. 63(10-11):867-85 (2011). PMID: 21718728.
  15. S. Cai, Q. Yang, T.R. Bagby, M.L. Forrest.Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles.Adv. Drug. Deliv. Rev. 63(10-11):901-908 (2011). PMID: 21712055.
  16. S.K. Nune, P. Gunda, P.K. Thallapally, Y.Y. Lin, M.L. Forrest, C.J. Berkland.Nanoparticles for biomedical imaging.Expert Opin. Drug Deliv. 6(11):1175-94 (2009). PMID: 19743894.
  17. S. Cohen, N. Rockefeller, R. Makerji, D. Durham, M. Forrest, S. Cai, M. Cohen, Y. Shnayder. “Efficacy and Toxicity of Peritumoral Delivery of Nanoconjugated Cisplatin in an In Vivo Murine Model of Head and Neck Squamous Cell Carcinoma.JAMA Otolaryngology-Head & Neck Surgery139(4):382-7 (2013).
  18. Q. Yang, D.J. Aires, S. Cai, G.R. Fraga, D. Zhang, C.Z. Li, M.L. Forrest. “In vivo efficacy of nano hyaluronan-conjugated cisplatin for treatment of murine melanoma.” J. Drugs Dermatol. 13(3):283-7 (2014).
  19. Y. Zhao, T. Zhang, S. Duan, N.M. Davies, M.L.Forrest. “CD44-Tropic Polymeric Nanocarrier for Breast Cancer Targeted Rapamycin Chemotherapy”. Nanomedicine: NBM pii:S1549-9634(14)00118-X (2014).
  20. S. Cai, A. Alhowyan, Q. Yang, W.C.M. Forrest, Y. Shnayder, M.L. Forrest. “Cellular Uptake and Internalization of Hyaluronan-based Doxorubicin and Cisplatin Conjugates” J. Drug Targeting, 22(7):648-57 (2014).
  21. M. L. Forrest, T. Zhang, Q. Yang, Forrest W C, S. Cai. “A Lanthanum-Tagged Chemotherapeutic Agent HA-Pt to Track the In vivo Distribution of Hyaluronic Acid Complexes.” BAOJ Pharm Sci 002. (2015).
  22. M.W. Sim, P.T. Grogan, C. Subramanian, C.R. Bradford, T.E. Carey, M.L. Forrest, M.E. Prince, M.S. Cohen. “Effects of Peritumoral Nanoconjugated Cisplatin on Laryngeal Cancer Stem Cells.The Laryngoscope. 126(5):E184-90 (2016). PMID: 26690734.
  23. C. Kuehl, T. Zhang. L.M. Kaminskas, C.J.H. Porter, N.M. Davies, M.L. Forrest, C. Berkland. “Hylauronic acid molecular weight determines lung clearance and biodistribution after instillation.Molec. Ther. 13(6):1904-14 (2016). PMID 2715708.
  24. T. Zhang, S. Cai, C. Groer, W.C. Forrest, Q. Yang, E. Mohr, J. Douglas, D. Aires, S.M. Axiak-Bechtel, K.A. Selting, J.A. Swarz, D.J. Tate, J.N. Bryan, M.L. Forrest. “Hyaluronan-lysine cisplatin drug carrier for treatment of localized cancers: pharmacokinetics, tolerability, and efficacy in rodents and canines.J. Pharm. Sci. 105(6):1891-900. PMID: 27155765.
  25. Ti Zhang, Shuang Cai, W.C. Forrest, Eva Mohr, Qiuhong Yang, and M. Laird Forrest. “Development and Validation of an Inductively Coupled Plasma Mass Spectrometry Method for Quantitative Analysis of Platinum in Plasma, Urine, and Tissues.Appl. Spectrosc., 70(9):1529-36 (2016). PMID 27527103
  26. S. Ishiguro, S. Cai, D. Uppalapati, K. Turner, T. Zhang, W.C. Forrest, M.L. Forrest, M. Tamura. “Intratracheal administration of hyaluronan-cisplatin conjugate nanoparticles significantly attenuates lung cancer growth in mice.Pharm. Res., 33(10):2517-29 (2016). PMID 27335023.
  27. S. Cai, T. Zhang, W.C. Forrest, Y. Qiuhong, C. Groer, E. Mohr, D.J. Aires, M. S.M. Axiak-Bechtel, B.K. Flesner, C.J. Henry, K.A. Selting, D. Tate, J.A. Swarz, J.N. Bryan, M.L. Forrest. “Phase I/II Clinical Trial of Hyaluronan-Cisplatin Nanoconjugate for the Treatment of Spontaneous Canine Cancers.Am. J. Vet. Res., 77(9):1005-16 (2016). PMID 27580113.
    Additional Images
  28. S. Senadheera, T. Zhang, C.E. Groer, M.L. Forrest “Formation of platinum (II) as a six member ring for sustained polymeric delivery”. Eur. J. Med. Chem. 2017 (in press)