Benefits

Key safety and efficacy advantages include:

  1. Increased drug in tumor due to local injection, enabled by hyaluronan conjugation.
  2. Increased uptake by cancer cells because cancer CD44 binds hyaluronan.
  3. Increased drug into local lymph nodes due to normal lymphatic hyaluronan clearance
  4. Increased drug into local lymph nodes due to drug size in the 20-50 nm lymph node “sweet spot”
  5. Reduced toxicity due to lower overall dose enabled by high tumor penetration
  6. Reduced toxicity due to lower peak blood level at any given dose.